7T7H

Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with inhibitor CP100356

Summary for 7T7H

• Entry DOI: 10.2210/pdb7t7h/pdb
• Descriptor: DNA repair NTP-phosphohydrolase, SODIUM ION, 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine, ... (4 entities in total)
• Functional Keywords: decapping enzyme, nudix, inhibitor, viral protein-viral protein inhibitor complex, viral protein/viral protein inhibitor
• Biological source: Vaccinia virus Western Reserve
• Total number of polymer chains: 2
• Total formula weight: 53371.42

Authors

Peters, J.K.,Gross, J.D. (deposition date: 2021-12-15, release date: 2022-06-15, Last modification date: 2023-10-18)

• Primary citation: Bednarczyk, M.,Peters, J.K.,Kasprzyk, R.,Starek, J.,Warminski, M.,Spiewla, T.,Mugridge, J.S.,Gross, J.D.,Jemielity, J.,Kowalska, J.; Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9.; Acs Chem.Biol., 17:1460-1471, 2022; PubMed: 35576528; DOI: 10.1021/acschembio.2c00049

Experimental method

X-RAY DIFFRACTION (1.78000262178 Å)