7T6X

Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs

Summary for 7T6X

• Entry DOI: 10.2210/pdb7t6x/pdb
• EMDB information: 25730
• Descriptor: Envelope glycoprotein E2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hepatitis c virus, e1e2, viral protein-immune system complex, antibody-antigen complex, viral protein/immune system
• Biological source: Hepacivirus C; More
• Total number of polymer chains: 8
• Total formula weight: 253883.93

Authors

Torrents de la Pena, A.,Ward, A.B.,Eshun-Wilson, L.,Lander, G.C. (deposition date: 2021-12-14, release date: 2022-11-02)

• Primary citation: Torrents de la Pena, A.,Sliepen, K.,Eshun-Wilson, L.,Newby, M.L.,Allen, J.D.,Zon, I.,Koekkoek, S.,Chumbe, A.,Crispin, M.,Schinkel, J.,Lander, G.C.,Sanders, R.W.,Ward, A.B.; Structure of the hepatitis C virus E1E2 glycoprotein complex.; Science, 378:263-269, 2022; PubMed: 36264808; DOI: 10.1126/science.abn9884

Experimental method

ELECTRON MICROSCOPY (3.83 Å)