7T6X

Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs

7T6X の概要

• エントリーDOI: 10.2210/pdb7t6x/pdb
• EMDBエントリー: 25730
• 分子名称: Envelope glycoprotein E2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• 機能のキーワード: hepatitis c virus, e1e2, viral protein-immune system complex, antibody-antigen complex, viral protein/immune system
• 由来する生物種: Hepacivirus C; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 253883.93

構造登録者

Torrents de la Pena, A.,Ward, A.B.,Eshun-Wilson, L.,Lander, G.C. (登録日: 2021-12-14, 公開日: 2022-11-02)

• 主引用文献: Torrents de la Pena, A.,Sliepen, K.,Eshun-Wilson, L.,Newby, M.L.,Allen, J.D.,Zon, I.,Koekkoek, S.,Chumbe, A.,Crispin, M.,Schinkel, J.,Lander, G.C.,Sanders, R.W.,Ward, A.B.; Structure of the hepatitis C virus E1E2 glycoprotein complex.; Science, 378:263-269, 2022; PubMed: 36264808; DOI: 10.1126/science.abn9884

実験手法

ELECTRON MICROSCOPY (3.83 Å)