7T6M

Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1

7T6M の概要

• エントリーDOI: 10.2210/pdb7t6m/pdb
• EMDBエントリー: 25716 25717 25718 25719 25720 25721 25722 25723 25724 25725
• 分子名称: Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
• 機能のキーワード: calcium, ion channel, kidney, transport protein
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 338124.61

構造登録者

Fluck, E.C.,Yazici, A.T.,Rohacs, T.,Moiseenkova-Bell, V.Y. (登録日: 2021-12-14, 公開日: 2022-05-04, 最終更新日: 2024-02-28)

• 主引用文献: Fluck, E.C.,Yazici, A.T.,Rohacs, T.,Moiseenkova-Bell, V.Y.; Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.; Cell Rep, 39:110737-110737, 2022; PubMed: 35476976; DOI: 10.1016/j.celrep.2022.110737

実験手法

ELECTRON MICROSCOPY (2.8 Å)