7T47

KRAS G12D (GppCp) with MRTX-1133

Summary for 7T47

• Entry DOI: 10.2210/pdb7t47/pdb
• Related: 7RPZ
• Descriptor: GTPase KRas, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (8 entities in total)
• Functional Keywords: oncoprotein, g12d, gcp, gtpase, kras4b, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23305.60

Authors

Thomas, N.C.,Gunn, R.J.,Lawson, J.D.,Wang, X.,Matthew, M.A. (deposition date: 2021-12-09, release date: 2022-03-16, Last modification date: 2023-10-18)

• Primary citation: Christensen, J.,Hallin, J.,Bowcut, V.,Calinsan, A.,Briere, D.,Hargis, L.,Engstrom, L.,Laguer, J.,Medwid, J.,Vanderpool, D.,Lifset, E.,Trinh, D.,Hoffman, N.,Wang, X.,Lawson, J.,Gunn, R.,Smith, C.,Thomas, N.,Martinson, M.,Bergstrom, A.,Sullivan, F.,Bouhana, K.,Winski, S.,He, L.,Julio, F.B.,Pavlicek, A.,Hafing, J.,Rahbaek, L.,Marx, M.,Olson, P.; A Non-covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of KRAS-dependent Signaling and Regression of KRASG12D-mutant Tumors; Nature, 2022; DOI: 10.21203/rs.3.rs-1261963/v1

Experimental method

X-RAY DIFFRACTION (1.27 Å)