7T2M
Crystal Structure of TEAD2 in a covalent complex with TED-664
Summary for 7T2M
Entry DOI | 10.2210/pdb7t2m/pdb |
Descriptor | Transcriptional enhancer factor TEF-4, (3aR,4R,7aS)-4-[2-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile (2 entities in total) |
Functional Keywords | tead, inhibitor, complex, covalent, allosteric, transcriptional enhancer factor tef-4, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 53563.67 |
Authors | Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. (deposition date: 2021-12-05, release date: 2023-06-14, Last modification date: 2023-10-25) |
Primary citation | Bum-Erdene, K.,Yeh, I.J.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Pollok, K.,Meroueh, S.O. Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. J.Med.Chem., 66:266-284, 2023 Cited by PubMed: 36562717DOI: 10.1021/acs.jmedchem.2c01189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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