7T2K

Crystal Structure of TEAD2 in a covalent complex with TED-661

Summary for 7T2K

• Entry DOI: 10.2210/pdb7t2k/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, 4-[2-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile (3 entities in total)
• Functional Keywords: tead, inhibitor, complex, covalent, allosteric, transcriptional enhancer factor tef-4, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 53860.90

Authors

Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. (deposition date: 2021-12-05, release date: 2023-06-14, Last modification date: 2023-10-25)

• Primary citation: Bum-Erdene, K.,Yeh, I.J.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Pollok, K.,Meroueh, S.O.; Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.; J.Med.Chem., 66:266-284, 2023; PubMed: 36562717; DOI: 10.1021/acs.jmedchem.2c01189

Experimental method

X-RAY DIFFRACTION (2.34 Å)