7T2H

CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT)

7T2H の概要

• エントリーDOI: 10.2210/pdb7t2h/pdb
• EMDBエントリー: 25613
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: gpcr, mu-opioid receptor, lofentanil (lft), mitragynine pseudoindoxyl (mp), membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 154135.81

構造登録者

Seven, A.B.,Qu, Q.,Huang, W.,Robertson, M.J.,Kobilka, B.K.,Skiniotis, G. (登録日: 2021-12-04, 公開日: 2022-12-07, 最終更新日: 2022-12-14)

• 主引用文献: Qu, Q.,Huang, W.,Aydin, D.,Paggi, J.M.,Seven, A.B.,Wang, H.,Chakraborty, S.,Che, T.,DiBerto, J.F.,Robertson, M.J.,Inoue, A.,Suomivuori, C.M.,Roth, B.L.,Majumdar, S.,Dror, R.O.,Kobilka, B.K.,Skiniotis, G.; Insights into distinct signaling profiles of the mu OR activated by diverse agonists.; Nat.Chem.Biol., 2022; PubMed: 36411392; DOI: 10.1038/s41589-022-01208-y

実験手法

ELECTRON MICROSCOPY (3.2 Å)