7T1K
Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide
Summary for 7T1K
Entry DOI | 10.2210/pdb7t1k/pdb |
Descriptor | Tyrosine-protein kinase Fes/Fps, Synthetic phosphotyrosine-containing Ezrin-derived peptide, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | src homology 2 (sh2), superbinder, engineered, phage display, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 12813.27 |
Authors | Martyn, G.D.,Singer, A.U.,Veggiani, G.,Kurinov, I.,Sicheri, F.,Sidhu, S.S. (deposition date: 2021-12-02, release date: 2022-08-24, Last modification date: 2023-11-15) |
Primary citation | Martyn, G.D.,Veggiani, G.,Kusebauch, U.,Morrone, S.R.,Yates, B.P.,Singer, A.U.,Tong, J.,Manczyk, N.,Gish, G.,Sun, Z.,Kurinov, I.,Sicheri, F.,Moran, M.F.,Moritz, R.L.,Sidhu, S.S. Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17:1472-1484, 2022 Cited by PubMed: 35613471DOI: 10.1021/acschembio.2c00051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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