7T1K

Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide

7T1K の概要

• エントリーDOI: 10.2210/pdb7t1k/pdb
• 分子名称: Tyrosine-protein kinase Fes/Fps, Synthetic phosphotyrosine-containing Ezrin-derived peptide, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: src homology 2 (sh2), superbinder, engineered, phage display, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 12813.27

構造登録者

Martyn, G.D.,Singer, A.U.,Veggiani, G.,Kurinov, I.,Sicheri, F.,Sidhu, S.S. (登録日: 2021-12-02, 公開日: 2022-08-24, 最終更新日: 2023-11-15)

• 主引用文献: Martyn, G.D.,Veggiani, G.,Kusebauch, U.,Morrone, S.R.,Yates, B.P.,Singer, A.U.,Tong, J.,Manczyk, N.,Gish, G.,Sun, Z.,Kurinov, I.,Sicheri, F.,Moran, M.F.,Moritz, R.L.,Sidhu, S.S.; Engineered SH2 Domains for Targeted Phosphoproteomics.; Acs Chem.Biol., 17:1472-1484, 2022; PubMed: 35613471; DOI: 10.1021/acschembio.2c00051

実験手法

X-RAY DIFFRACTION (1.25 Å)