7SS1
The structure of NTMT1 in complex with compound GD433
Summary for 7SS1
Entry DOI | 10.2210/pdb7ss1/pdb |
Descriptor | N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate (3 entities in total) |
Functional Keywords | ntmt1, methyltransferase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 56219.94 |
Authors | Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N. (deposition date: 2021-11-09, release date: 2022-11-16, Last modification date: 2023-10-18) |
Primary citation | Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N. Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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