7SS1

The structure of NTMT1 in complex with compound GD433

7SS1 の概要

• エントリーDOI: 10.2210/pdb7ss1/pdb
• 分子名称: N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate (3 entities in total)
• 機能のキーワード: ntmt1, methyltransferase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56219.94

構造登録者

Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N. (登録日: 2021-11-09, 公開日: 2022-11-16, 最終更新日: 2023-10-18)

• 主引用文献: Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N.; Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2; To Be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)