7SQM

Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria

Summary for 7SQM

• Entry DOI: 10.2210/pdb7sqm/pdb
• Descriptor: Serine/threonine-protein kinase haspin, 1-[(4S)-5-(2,4-difluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-methylpiperidin-4-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: imidazothiadiazole, antimalarial, single-dose cure, fast-acting, malaria, antiviral protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 40916.76

Authors

Shu, W.,Yokokawa, F. (deposition date: 2021-11-05, release date: 2021-12-29, Last modification date: 2023-10-18)

• Primary citation: Rogers, W.O.,Wongsrichanalai, C.; Failure of artesunate-mefloquine combination therapy for uncompli-cated Plasmodium falciparum malaria in southern Cambodia.; Malar. J., 2009, 8, 10:8-10, 2009

Experimental method

X-RAY DIFFRACTION (1.78 Å)