7SQA

PPAR gamma LBD bound to SR10221 and SMRT corepressor motif

7SQA の概要

• エントリーDOI: 10.2210/pdb7sqa/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 2, (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid, ... (4 entities in total)
• 機能のキーワード: inverse agonist, nuclear receptor, ligand binding domain, corepressor, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 72923.26

構造登録者

Frkic, R.L.,Pederick, J.L.,Bruning, J.B. (登録日: 2021-11-05, 公開日: 2023-05-10, 最終更新日: 2023-10-25)

• 主引用文献: Frkic, R.L.,Pederick, J.L.,Horsfall, A.J.,Jovcevski, B.,Crame, E.E.,Kowalczyk, W.,Pukala, T.L.,Chang, M.R.,Zheng, J.,Blayo, A.L.,Abell, A.D.,Kamenecka, T.M.,Harbort, J.S.,Harmer, J.R.,Griffin, P.R.,Bruning, J.B.; PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.; Acs Chem.Biol., 18:1115-1123, 2023; PubMed: 37146157; DOI: 10.1021/acschembio.2c00917

実験手法

X-RAY DIFFRACTION (2.499 Å)