7SP0

Crystal structure of human SFPQ L534I mutant in complex with zinc

Summary for 7SP0

• Entry DOI: 10.2210/pdb7sp0/pdb
• Descriptor: Splicing factor, proline- and glutamine-rich, ZINC ION (3 entities in total)
• Functional Keywords: sfpq, dbhs protein, rrm, zn, polymerization, nuclear protein, als mutation, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 60318.91

Authors

Lee, M. (deposition date: 2021-11-01, release date: 2022-10-12, Last modification date: 2023-10-18)

• Primary citation: Widagdo, J.,Udagedara, S.,Bhembre, N.,Tan, J.Z.A.,Neureiter, L.,Huang, J.,Anggono, V.,Lee, M.; Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.; Open Biology, 12:220187-220187, 2022; PubMed: 36168806; DOI: 10.1098/rsob.220187

Experimental method

X-RAY DIFFRACTION (1.83 Å)