7SP0
Crystal structure of human SFPQ L534I mutant in complex with zinc
Summary for 7SP0
Entry DOI | 10.2210/pdb7sp0/pdb |
Descriptor | Splicing factor, proline- and glutamine-rich, ZINC ION (3 entities in total) |
Functional Keywords | sfpq, dbhs protein, rrm, zn, polymerization, nuclear protein, als mutation, rna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 60318.91 |
Authors | |
Primary citation | Widagdo, J.,Udagedara, S.,Bhembre, N.,Tan, J.Z.A.,Neureiter, L.,Huang, J.,Anggono, V.,Lee, M. Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. Open Biology, 12:220187-220187, 2022 Cited by PubMed: 36168806DOI: 10.1098/rsob.220187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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