7SNN

Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl)acetamide

7SNN の概要

• エントリーDOI: 10.2210/pdb7snn/pdb
• 関連するPDBエントリー: 7SNL
• 分子名称: Capsid protein p24, IODIDE ION, N-[(1S)-1-(3-{4-chloro-3-[(methanesulfonyl)amino]-1-methyl-1H-indazol-7-yl}-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3aM)-3-(difluoromethyl)cyclopenta[c]pyrazol-1(2H)-yl]acetamide, ... (5 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26845.29

構造登録者

Bester, S.M.,Kvaratskhelia, M. (登録日: 2021-10-28, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Adu-Ampratwum, D.,Haney, R.,Bester, S.M.,Annamalai, A.S.,Wei, G.,Fuchs, J.R.,Kvaratskhelia, M.; Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl)acetamide; To Be Published,

実験手法

X-RAY DIFFRACTION (2.37 Å)