7SL5

Crystal Structure of VP12E7 Fab in complex with SARS-CoV-2 S fusion peptide

7SL5 の概要

• エントリーDOI: 10.2210/pdb7sl5/pdb
• 分子名称: Heavy chain VP12E7 Fab, Light chain VP12E7 Fab, PRO-SER-LYS-ARG-SER-PHE-ILE-GLU-ASP-LEU-LEU-PHE-ASN, ... (4 entities in total)
• 機能のキーワード: sars-cov-2 spike, covid-19, fusion peptide, fab, viral protein, viral protein-immune system complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 201268.60

構造登録者

Tortorici, M.A.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-10-22, 公開日: 2022-07-20, 最終更新日: 2023-10-18)

• 主引用文献: Low, J.S.,Jerak, J.,Tortorici, M.A.,McCallum, M.,Pinto, D.,Cassotta, A.,Foglierini, M.,Mele, F.,Abdelnabi, R.,Weynand, B.,Noack, J.,Montiel-Ruiz, M.,Bianchi, S.,Benigni, F.,Sprugasci, N.,Joshi, A.,Bowen, J.E.,Stewart, C.,Rexhepaj, M.,Walls, A.C.,Jarrossay, D.,Morone, D.,Paparoditis, P.,Garzoni, C.,Ferrari, P.,Ceschi, A.,Neyts, J.,Purcell, L.A.,Snell, G.,Corti, D.,Lanzavecchia, A.,Veesler, D.,Sallusto, F.; ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.; Science, 377:735-742, 2022; PubMed: 35857703; DOI: 10.1126/science.abq2679

実験手法

X-RAY DIFFRACTION (2.5 Å)