7SK6

Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab

7SK6 の概要

• エントリーDOI: 10.2210/pdb7sk6/pdb
• EMDBエントリー: 25174
• 分子名称: Atypical chemokine receptor 3, Stromal cell-derived factor 1, CID24 Fab light chain, ... (4 entities in total)
• 機能のキーワード: atypical chemokine receptor, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102237.32

構造登録者

Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Handel, T.M.,Tesmer, J.J.G. (登録日: 2021-10-19, 公開日: 2022-07-27)

• 主引用文献: Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Eberle, S.A.,Dominik, P.K.,Deneka, D.,Zhang, P.,Schall, T.J.,Kossiakoff, A.A.,Tesmer, J.J.G.,Handel, T.M.; Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.; Sci Adv, 8:eabn8063-eabn8063, 2022; PubMed: 35857509; DOI: 10.1126/sciadv.abn8063

実験手法

ELECTRON MICROSCOPY (4 Å)