7SK2

Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation

Summary for 7SK2

Entry DOI	10.2210/pdb7sk2/pdb
EMDB information	25170
Descriptor	Sodium- and chloride-dependent GABA transporter 1, Tiagabine (2 entities in total)
Functional Keywords	neurotransmitter transporter, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	65262.34
Authors	Gati, C.,Motiwala, Z.,Aduri, N.G.,Shaye, H.,Han, G.W.,Cherezov, V. (deposition date: 2021-10-19, release date: 2022-06-08, Last modification date: 2022-07-06)
Primary citation	Motiwala, Z.,Aduri, N.G.,Shaye, H.,Han, G.W.,Lam, J.H.,Katritch, V.,Cherezov, V.,Gati, C. Structural basis of GABA reuptake inhibition. Nature, 606:820-826, 2022 Cited by PubMed: 35676483 DOI: 10.1038/s41586-022-04814-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.82 Å)

Structure validation