7SIL

Structure of positive allosteric modulator-bound active human calcium-sensing receptor

7SIL の概要

• エントリーDOI: 10.2210/pdb7sil/pdb
• EMDBエントリー: 25143
• 分子名称: Isoform 1 of Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: calcium-sensing receptor, cryo-em structure, allosteric modulation, activation mechanism, symmetry, membrane protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 206267.70

構造登録者

Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. (登録日: 2021-10-14, 公開日: 2022-01-19)

• 主引用文献: Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R.; Symmetric activation and modulation of the human calcium-sensing receptor.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34916296; DOI: 10.1073/pnas.2115849118

実験手法

ELECTRON MICROSCOPY (2.7 Å)