7SHI
Crystal Structure of Cytochrome P450 AmphL from Streptomyces nodosus and the Structural Basis for Substrate Selectivity in Macrolide Metabolizing P450s
Summary for 7SHI
Entry DOI | 10.2210/pdb7shi/pdb |
Descriptor | AmphL, PROTOPORPHYRIN IX CONTAINING FE, Amphotericin B, ... (5 entities in total) |
Functional Keywords | amphotericin b, hydroxylase, p450, cytochrome, oxidoreductase |
Biological source | Streptomyces nodosus |
Total number of polymer chains | 2 |
Total formula weight | 89726.18 |
Authors | Amaya, J.A.,Poulos, T.L. (deposition date: 2021-10-08, release date: 2022-03-09, Last modification date: 2024-06-19) |
Primary citation | Amaya, J.A.,Lamb, D.C.,Kelly, S.L.,Caffrey, P.,Murarka, V.C.,Poulos, T.L. Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s. J.Biol.Chem., 298:101746-101746, 2022 Cited by PubMed: 35189143DOI: 10.1016/j.jbc.2022.101746 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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