7SH5

Crystal structure of CYP142A3 from Mycobacterium ulcerans bound to Cholest-4-en-3-one

Summary for 7SH5

• Entry DOI: 10.2210/pdb7sh5/pdb
• Descriptor: Cytochrome P450 142A3, PROTOPORPHYRIN IX CONTAINING FE, (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, ... (6 entities in total)
• Functional Keywords: p450, heme, mono-oxygenase, lipid, catabolism, cholesterol, cholest-4-en-3-one, mycobacteria, tuberculosis, ulcerans, lipid binding protein, oxidoreductase
• Biological source: Mycobacterium ulcerans
• Total number of polymer chains: 4
• Total formula weight: 186166.54

Authors

Doherty, D.Z.,Bell, S.G.,Bruning, J. (deposition date: 2021-10-08, release date: 2022-10-05, Last modification date: 2023-10-18)

• Primary citation: Ghith, A.,Doherty, D.Z.,Bruning, J.B.,Russell, R.A.,De Voss, J.J.,Bell, S.G.; The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum.; Acs Infect Dis., 8:1606-1617, 2022; PubMed: 35881654; DOI: 10.1021/acsinfecdis.2c00215

Experimental method

X-RAY DIFFRACTION (1.83 Å)