7SH5

Crystal structure of CYP142A3 from Mycobacterium ulcerans bound to Cholest-4-en-3-one

7SH5 の概要

• エントリーDOI: 10.2210/pdb7sh5/pdb
• 分子名称: Cytochrome P450 142A3, PROTOPORPHYRIN IX CONTAINING FE, (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, ... (6 entities in total)
• 機能のキーワード: p450, heme, mono-oxygenase, lipid, catabolism, cholesterol, cholest-4-en-3-one, mycobacteria, tuberculosis, ulcerans, lipid binding protein, oxidoreductase
• 由来する生物種: Mycobacterium ulcerans
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 186166.54

構造登録者

Doherty, D.Z.,Bell, S.G.,Bruning, J. (登録日: 2021-10-08, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Ghith, A.,Doherty, D.Z.,Bruning, J.B.,Russell, R.A.,De Voss, J.J.,Bell, S.G.; The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum.; Acs Infect Dis., 8:1606-1617, 2022; PubMed: 35881654; DOI: 10.1021/acsinfecdis.2c00215

実験手法

X-RAY DIFFRACTION (1.83 Å)