7SH0
CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE
Summary for 7SH0
Entry DOI | 10.2210/pdb7sh0/pdb |
Descriptor | Endoplasmic reticulum aminopeptidase 2, ZINC ION, (2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide, ... (7 entities in total) |
Functional Keywords | aminopeptidase, erap2 structure, enzyme inhibitor, antigen processing, immune system, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 225329.06 |
Authors | Li, L.,Bouvier, M. (deposition date: 2021-10-07, release date: 2022-07-20, Last modification date: 2023-10-25) |
Primary citation | Camberlein, V.,Fleau, C.,Sierocki, P.,Li, L.,Gealageas, R.,Bosc, D.,Guillaume, V.,Warenghem, S.,Leroux, F.,Rosell, M.,Cheng, K.,Medve, L.,Prigent, M.,Decanter, M.,Piveteau, C.,Biela, A.,Eveque, M.,Dumont, J.,Mpakali, A.,Giastas, P.,Herledan, A.,Couturier, C.,Haupenthal, J.,Lesire, L.,Hirsch, A.K.H.,Deprez, B.,Stratikos, E.,Bouvier, M.,Deprez-Poulain, R. Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis. Angew.Chem.Int.Ed.Engl., 61:e202203560-e202203560, 2022 Cited by PubMed: 35904863DOI: 10.1002/anie.202203560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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