7SGI

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14

7SGI の概要

• エントリーDOI: 10.2210/pdb7sgi/pdb
• 分子名称: Polyamine deacetylase HDAC10, 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, ZINC ION, ... (7 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75786.48

構造登録者

Herbst-Gervasoni, C.J.,Christianson, D.W. (登録日: 2021-10-05, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Steimbach, R.R.,Herbst-Gervasoni, C.J.,Lechner, S.,Stewart, T.M.,Klinke, G.,Ridinger, J.,Geraldy, M.N.E.,Tihanyi, G.,Foley, J.R.,Uhrig, U.,Kuster, B.,Poschet, G.,Casero Jr., R.A.,Medard, G.,Oehme, I.,Christianson, D.W.,Gunkel, N.,Miller, A.K.; Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.; J.Am.Chem.Soc., 144:18861-18875, 2022; PubMed: 36200994; DOI: 10.1021/jacs.2c05030

実験手法

X-RAY DIFFRACTION (2.15 Å)