7SFG

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Cofactor SAM

7SFG の概要

• エントリーDOI: 10.2210/pdb7sfg/pdb
• 分子名称: DNA (cytosine-5)-methyltransferase 1, DNA Strand 1, DNA Strand 2, ... (8 entities in total)
• 機能のキーワード: epigentics, dna methytransferase fold, maintenance methylation, inhibition, dna binding protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107141.08

構造登録者

Horton, J.R.,Pathuri, S.,Cheng, X. (登録日: 2021-10-03, 公開日: 2022-03-30, 最終更新日: 2023-10-18)

• 主引用文献: Horton, J.R.,Pathuri, S.,Wong, K.,Ren, R.,Rueda, L.,Fosbenner, D.T.,Heerding, D.A.,McCabe, M.T.,Pappalardi, M.B.,Zhang, X.,King, B.W.,Cheng, X.; Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.; Structure, 30:793-802.e5, 2022; PubMed: 35395178; DOI: 10.1016/j.str.2022.03.009

実験手法

X-RAY DIFFRACTION (2.43 Å)