7SEY
M. tb EgtD in complex with SGH
Summary for 7SEY
| Entry DOI | 10.2210/pdb7sey/pdb |
| Descriptor | Histidine N-alpha-methyltransferase, 2-amino-1-[(3S)-3-methyl-4-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepan-1-yl]ethan-1-one (3 entities in total) |
| Functional Keywords | ergothioneine biosynthesis pathway, rossmann fold domain, bi-substrate analogs, sam dependent methyltransferase, transferase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 1 |
| Total formula weight | 35691.26 |
| Authors | Sudasinghe, T.D.,Ronning, D.R. (deposition date: 2021-10-02, release date: 2021-12-01, Last modification date: 2023-10-18) |
| Primary citation | Sudasinghe, T.D.,Banco, M.T.,Ronning, D.R. Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11:22240-22240, 2021 Cited by PubMed: 34782676DOI: 10.1038/s41598-021-01526-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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