7SEX
M. tb EgtD in complex with TGX221
Summary for 7SEX
Entry DOI | 10.2210/pdb7sex/pdb |
Descriptor | Histidine N-alpha-methyltransferase, 7-methyl-2-morpholin-4-yl-9-[(1~{R})-1-phenylazanylethyl]-3~{H}-pyrido[1,2-a]pyrimidin-4-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | ergothioneine biosynthesis pathway, rossmann fold domain, histidine/histamine derivatives, sam dependent methyltransferase, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 35863.42 |
Authors | Sudasinghe, T.D.,Ronning, D.R. (deposition date: 2021-10-02, release date: 2021-12-01, Last modification date: 2023-10-18) |
Primary citation | Sudasinghe, T.D.,Banco, M.T.,Ronning, D.R. Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11:22240-22240, 2021 Cited by PubMed: 34782676DOI: 10.1038/s41598-021-01526-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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