7SEX

M. tb EgtD in complex with TGX221

7SEX の概要

• エントリーDOI: 10.2210/pdb7sex/pdb
• 分子名称: Histidine N-alpha-methyltransferase, 7-methyl-2-morpholin-4-yl-9-[(1~{R})-1-phenylazanylethyl]-3~{H}-pyrido[1,2-a]pyrimidin-4-one, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: ergothioneine biosynthesis pathway, rossmann fold domain, histidine/histamine derivatives, sam dependent methyltransferase, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35863.42

構造登録者

Sudasinghe, T.D.,Ronning, D.R. (登録日: 2021-10-02, 公開日: 2021-12-01, 最終更新日: 2023-10-18)

• 主引用文献: Sudasinghe, T.D.,Banco, M.T.,Ronning, D.R.; Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.; Sci Rep, 11:22240-22240, 2021; PubMed: 34782676; DOI: 10.1038/s41598-021-01526-6

実験手法

X-RAY DIFFRACTION (2.2 Å)