7SEC

Crystal structure of human Fibrillarin in complex with compound 1a

Summary for 7SEC

Entry DOI	10.2210/pdb7sec/pdb
Descriptor	rRNA 2'-O-methyltransferase fibrillarin, FORMIC ACID, 2-[(8S)-4-oxo-2-(trifluoromethyl)-4,5-dihydropyrazolo[1,5-a]pyrazin-6-yl]acetamide, ... (5 entities in total)
Functional Keywords	methyltransferase, s-adenosyl methionine, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	54407.99
Authors	Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,von Itzstein, M.,Ve, T. (deposition date: 2021-09-30, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,Itzstein, M.V.,Ve, T. Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15:-, 2021 Cited by PubMed: 35056083 DOI: 10.3390/ph15010026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation