7SEC

Crystal structure of human Fibrillarin in complex with compound 1a

7SEC の概要

• エントリーDOI: 10.2210/pdb7sec/pdb
• 分子名称: rRNA 2'-O-methyltransferase fibrillarin, FORMIC ACID, 2-[(8S)-4-oxo-2-(trifluoromethyl)-4,5-dihydropyrazolo[1,5-a]pyrazin-6-yl]acetamide, ... (5 entities in total)
• 機能のキーワード: methyltransferase, s-adenosyl methionine, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54407.99

構造登録者

Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,von Itzstein, M.,Ve, T. (登録日: 2021-09-30, 公開日: 2022-02-09, 最終更新日: 2023-10-18)

• 主引用文献: Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,Itzstein, M.V.,Ve, T.; Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.; Pharmaceuticals, 15:-, 2021; PubMed: 35056083; DOI: 10.3390/ph15010026

実験手法

X-RAY DIFFRACTION (1.9 Å)