7SBU

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a highly potent antibody J08 Fab

7SBU の概要

• エントリーDOI: 10.2210/pdb7sbu/pdb
• 分子名称: Spike protein S1, J08 Fab heavy chain, J08 Fab light chain, ... (6 entities in total)
• 機能のキーワード: sars-cov-2, antibody, spike, coronavirus, covid-19, immune system, viral protein-immune system complex, neutralizing antibody, receptor binding domain
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70691.96

構造登録者

Liu, H.,Wilson, I.A. (登録日: 2021-09-25, 公開日: 2022-05-11, 最終更新日: 2023-10-18)

• 主引用文献: Torres, J.L.,Ozorowski, G.,Andreano, E.,Liu, H.,Copps, J.,Piccini, G.,Donnici, L.,Conti, M.,Planchais, C.,Planas, D.,Manganaro, N.,Pantano, E.,Paciello, I.,Pileri, P.,Bruel, T.,Montomoli, E.,Mouquet, H.,Schwartz, O.,Sala, C.,De Francesco, R.,Wilson, I.A.,Rappuoli, R.,Ward, A.B.; Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.; Proc.Natl.Acad.Sci.USA, 119:e2120976119-e2120976119, 2022; PubMed: 35549549; DOI: 10.1073/pnas.2120976119

実験手法

X-RAY DIFFRACTION (2.53 Å)