7SB7

Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

7SB7 の概要

• エントリーDOI: 10.2210/pdb7sb7/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid (3 entities in total)
• 機能のキーワード: inhibitor, complex, phosphonate, purine, transferase
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49330.04

構造登録者

Guddat, L.W.,Keough, D.T. (登録日: 2021-09-24, 公開日: 2022-03-02, 最終更新日: 2023-10-18)

• 主引用文献: Klejch, T.,Keough, D.T.,King, G.,Dolezelova, E.,Cesnek, M.,Budesinsky, M.,Zikova, A.,Janeba, Z.,Guddat, L.W.,Hockova, D.; Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.; J.Med.Chem., 65:4030-4057, 2022; PubMed: 35175749; DOI: 10.1021/acs.jmedchem.1c01881

実験手法

X-RAY DIFFRACTION (2.64716619036 Å)