7SA0
Crystal structure of CDK2 liganded with compound EF4195
Summary for 7SA0
Entry DOI | 10.2210/pdb7sa0/pdb |
Descriptor | Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 2-{[(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amino}-5-(trifluoromethyl)benzoic acid, ... (4 entities in total) |
Functional Keywords | allosteric inhibitor drug development kinase, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34973.47 |
Authors | Sun, L.,Schonbrunn, E. (deposition date: 2021-09-21, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Sun, L.,Schonbrunn, E. Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2) To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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