7S9X

Crystal structure of CDK2 liganded with compound WN378

Summary for 7S9X

Entry DOI	10.2210/pdb7s9x/pdb
Descriptor	Cyclin-dependent kinase 2, 2-[(9H-carbazol-3-yl)amino]-5-(trifluoromethyl)benzoic acid (3 entities in total)
Functional Keywords	allosteric inhibitor, drug development, kinase, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34346.81
Authors	Sun, L.,Schonbrunn, E. (deposition date: 2021-09-21, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Sun, L.,Schonbrunn, E. Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2) To Be Published,
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation