7S8B

Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red

7S8B の概要

• エントリーDOI: 10.2210/pdb7s8b/pdb
• 関連するPDBエントリー: 7S88 7S89
• EMDBエントリー: 24890 24891 24892
• 分子名称: Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
• 機能のキーワード: transient receptor potential v family member 6, trp, channel, ruthenium red, channel blocker, antagonist, cnw11, nanodiscs, trpv6, membrane protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 344556.24

構造登録者

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (登録日: 2021-09-17, 公開日: 2021-11-17)

• 主引用文献: Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I.; Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.; Nat Commun, 12:6284-6284, 2021; PubMed: 34725357; DOI: 10.1038/s41467-021-26608-x

実験手法

ELECTRON MICROSCOPY (2.43 Å)