7S7M
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Summary for 7S7M
Entry DOI | 10.2210/pdb7s7m/pdb |
Related | 6PTC |
Descriptor | Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | metalloproteinase, metalloproteinase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 40260.10 |
Authors | Coban, M.,Raeeszadeh-Sarmazdeh, M.,Sankaran, B.,Hockla, A.,Radisky, E.S. (deposition date: 2021-09-16, release date: 2022-03-16, Last modification date: 2023-10-18) |
Primary citation | Raeeszadeh-Sarmazdeh, M.,Coban, M.,Mahajan, S.,Hockla, A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298:101654-101654, 2022 Cited by PubMed: 35101440DOI: 10.1016/j.jbc.2022.101654 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report