7S7M

Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)

7S7M の概要

• エントリーDOI: 10.2210/pdb7s7m/pdb
• 関連するPDBエントリー: 6PTC
• 分子名称: Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: metalloproteinase, metalloproteinase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40260.10

構造登録者

Coban, M.,Raeeszadeh-Sarmazdeh, M.,Sankaran, B.,Hockla, A.,Radisky, E.S. (登録日: 2021-09-16, 公開日: 2022-03-16, 最終更新日: 2023-10-18)

• 主引用文献: Raeeszadeh-Sarmazdeh, M.,Coban, M.,Mahajan, S.,Hockla, A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S.; Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.; J.Biol.Chem., 298:101654-101654, 2022; PubMed: 35101440; DOI: 10.1016/j.jbc.2022.101654

実験手法

X-RAY DIFFRACTION (3 Å)