7S5P

Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibody CS23

7S5P の概要

• エントリーDOI: 10.2210/pdb7s5p/pdb
• 分子名称: Spike protein S1, CS23 Heavy chain, CS23 Light chain, ... (7 entities in total)
• 機能のキーワード: sars-cov-2, coronavirus, antibody, fab, voc, beta, b.1.351, spike, rbd, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 73610.49

構造登録者

Yuan, M.,Wilson, I.A. (登録日: 2021-09-11, 公開日: 2022-03-09, 最終更新日: 2023-10-18)

• 主引用文献: Reincke, S.M.,Yuan, M.,Kornau, H.C.,Corman, V.M.,van Hoof, S.,Sanchez-Sendin, E.,Ramberger, M.,Yu, W.,Hua, Y.,Tien, H.,Schmidt, M.L.,Schwarz, T.,Jeworowski, L.M.,Brandl, S.E.,Rasmussen, H.F.,Homeyer, M.A.,Stoffler, L.,Barner, M.,Kunkel, D.,Huo, S.,Horler, J.,von Wardenburg, N.,Kroidl, I.,Eser, T.M.,Wieser, A.,Geldmacher, C.,Hoelscher, M.,Ganzer, H.,Weiss, G.,Schmitz, D.,Drosten, C.,Pruss, H.,Wilson, I.A.,Kreye, J.; SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.; Science, 375:782-787, 2022; PubMed: 35076281; DOI: 10.1126/science.abm5835

実験手法

X-RAY DIFFRACTION (2.86 Å)