7S5G
PCSK9 in complex with compound 19
Summary for 7S5G
Entry DOI | 10.2210/pdb7s5g/pdb |
Descriptor | Propeptide of Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, Z9J-ALA-DAL-PHE-FTR-PRO-THR-0A1-3WX, ... (6 entities in total) |
Functional Keywords | cholesterol, ldl receptor, egfa domain, protein binding, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 48074.09 |
Authors | Orth, P. (deposition date: 2021-09-10, release date: 2021-11-03, Last modification date: 2024-04-24) |
Primary citation | Tucker, T.J.,Embrey, M.W.,Alleyne, C.,Amin, R.P.,Bass, A.,Bhatt, B.,Bianchi, E.,Branca, D.,Bueters, T.,Buist, N.,Ha, S.N.,Hafey, M.,He, H.,Higgins, J.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,Kuethe, J.T.,Li, N.,Murphy, B.,Orth, P.,Salowe, S.,Shahripour, A.,Tracy, R.,Wang, W.,Wu, C.,Xiong, Y.,Zokian, H.J.,Wood, H.B.,Walji, A. A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J.Med.Chem., 64:16770-16800, 2021 Cited by PubMed: 34704436DOI: 10.1021/acs.jmedchem.1c01599 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.041 Å) |
Structure validation
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