7S5G

PCSK9 in complex with compound 19

7S5G の概要

• エントリーDOI: 10.2210/pdb7s5g/pdb
• 分子名称: Propeptide of Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, Z9J-ALA-DAL-PHE-FTR-PRO-THR-0A1-3WX, ... (6 entities in total)
• 機能のキーワード: cholesterol, ldl receptor, egfa domain, protein binding, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48074.09

構造登録者

Orth, P. (登録日: 2021-09-10, 公開日: 2021-11-03, 最終更新日: 2024-04-24)

• 主引用文献: Tucker, T.J.,Embrey, M.W.,Alleyne, C.,Amin, R.P.,Bass, A.,Bhatt, B.,Bianchi, E.,Branca, D.,Bueters, T.,Buist, N.,Ha, S.N.,Hafey, M.,He, H.,Higgins, J.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,Kuethe, J.T.,Li, N.,Murphy, B.,Orth, P.,Salowe, S.,Shahripour, A.,Tracy, R.,Wang, W.,Wu, C.,Xiong, Y.,Zokian, H.J.,Wood, H.B.,Walji, A.; A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.; J.Med.Chem., 64:16770-16800, 2021; PubMed: 34704436; DOI: 10.1021/acs.jmedchem.1c01599

実験手法

X-RAY DIFFRACTION (2.041 Å)