7S5B
Unbound State of a De novo designed Protein Binder to the Human Interleukin-7 Receptor
Summary for 7S5B
Entry DOI | 10.2210/pdb7s5b/pdb |
Descriptor | Miniprotein Binder (2 entities in total) |
Functional Keywords | minibinder protein inhibitor cytokine receptor interleukin-7, de novo protein |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 12886.84 |
Authors | Walsh, S.T.R.,Cao, L.,Baker, D. (deposition date: 2021-09-10, release date: 2022-05-11, Last modification date: 2024-04-03) |
Primary citation | Cao, L.,Coventry, B.,Goreshnik, I.,Huang, B.,Sheffler, W.,Park, J.S.,Jude, K.M.,Markovic, I.,Kadam, R.U.,Verschueren, K.H.G.,Verstraete, K.,Walsh, S.T.R.,Bennett, N.,Phal, A.,Yang, A.,Kozodoy, L.,DeWitt, M.,Picton, L.,Miller, L.,Strauch, E.M.,DeBouver, N.D.,Pires, A.,Bera, A.K.,Halabiya, S.,Hammerson, B.,Yang, W.,Bernard, S.,Stewart, L.,Wilson, I.A.,Ruohola-Baker, H.,Schlessinger, J.,Lee, S.,Savvides, S.N.,Garcia, K.C.,Baker, D. Design of protein-binding proteins from the target structure alone. Nature, 605:551-560, 2022 Cited by PubMed: 35332283DOI: 10.1038/s41586-022-04654-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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