7S5B

Unbound State of a De novo designed Protein Binder to the Human Interleukin-7 Receptor

Summary for 7S5B

• Entry DOI: 10.2210/pdb7s5b/pdb
• Descriptor: Miniprotein Binder (2 entities in total)
• Functional Keywords: minibinder protein inhibitor cytokine receptor interleukin-7, de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 12886.84

Authors

Walsh, S.T.R.,Cao, L.,Baker, D. (deposition date: 2021-09-10, release date: 2022-05-11, Last modification date: 2024-04-03)

• Primary citation: Cao, L.,Coventry, B.,Goreshnik, I.,Huang, B.,Sheffler, W.,Park, J.S.,Jude, K.M.,Markovic, I.,Kadam, R.U.,Verschueren, K.H.G.,Verstraete, K.,Walsh, S.T.R.,Bennett, N.,Phal, A.,Yang, A.,Kozodoy, L.,DeWitt, M.,Picton, L.,Miller, L.,Strauch, E.M.,DeBouver, N.D.,Pires, A.,Bera, A.K.,Halabiya, S.,Hammerson, B.,Yang, W.,Bernard, S.,Stewart, L.,Wilson, I.A.,Ruohola-Baker, H.,Schlessinger, J.,Lee, S.,Savvides, S.N.,Garcia, K.C.,Baker, D.; Design of protein-binding proteins from the target structure alone.; Nature, 605:551-560, 2022; PubMed: 35332283; DOI: 10.1038/s41586-022-04654-9

Experimental method

X-RAY DIFFRACTION (1.5 Å)