7S3Y
Structure ofrat neuronal nitric oxide synthase heme domain in complex with 7-((3-(2-(6-aminopyridin-2-yl)ethyl)phenoxy)methyl)quinolin-2-amine
Summary for 7S3Y
Entry DOI | 10.2210/pdb7s3y/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 2 |
Total formula weight | 100449.10 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2021-09-08, release date: 2022-09-14, Last modification date: 2024-05-22) |
Primary citation | Lewis, M.C.,Weerawarna, P.M.,Li, H.,Murarka, V.,Silverman, R.B.,Poulos, T.L. Selective anti-MRSA inhibitors targeting bacterial nitric oxide synthase To be published, |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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