7S3C

Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide

7S3C の概要

• エントリーDOI: 10.2210/pdb7s3c/pdb
• 分子名称: Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3') (3 entities in total)
• 機能のキーワード: protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna-dna complex, rna binding protein/rna/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24709.67

構造登録者

Glasser, E.,Jenkins, J.L.,Kielkopf, C.L. (登録日: 2021-09-05, 公開日: 2022-05-25, 最終更新日: 2023-10-18)

• 主引用文献: Glasser, E.,Maji, D.,Biancon, G.,Puthenpeedikakkal, A.M.K.,Cavender, C.E.,Tebaldi, T.,Jenkins, J.L.,Mathews, D.H.,Halene, S.,Kielkopf, C.L.; Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.; Nucleic Acids Res., 50:5299-5312, 2022; PubMed: 35524551; DOI: 10.1093/nar/gkac287

実験手法

X-RAY DIFFRACTION (1.51 Å)