7S3B
Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide
Summary for 7S3B
Entry DOI | 10.2210/pdb7s3b/pdb |
Descriptor | Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), DI(HYDROXYETHYL)ETHER, ... (4 entities in total) |
Functional Keywords | rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna-dna complex, rna binding protein/rna/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 24937.91 |
Authors | Jenkins, J.L.,Henderson, S.,Kielkopf, C.L. (deposition date: 2021-09-05, release date: 2022-05-25, Last modification date: 2024-05-22) |
Primary citation | Glasser, E.,Maji, D.,Biancon, G.,Puthenpeedikakkal, A.M.K.,Cavender, C.E.,Tebaldi, T.,Jenkins, J.L.,Mathews, D.H.,Halene, S.,Kielkopf, C.L. Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50:5299-5312, 2022 Cited by PubMed: 35524551DOI: 10.1093/nar/gkac287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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