7S2Y
SAMHD1 HD domain bound to CNDAC
Summary for 7S2Y
Entry DOI | 10.2210/pdb7s2y/pdb |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 4-amino-1-{2-cyano-2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | samhd1, inhibitor, sapacitabine, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 259926.05 |
Authors | Digianantonio, K.M.,Xiong, Y. (deposition date: 2021-09-04, release date: 2021-10-27, Last modification date: 2023-10-18) |
Primary citation | Rothenburger, T.,Thomas, D.,Schreiber, Y.,Wratil, P.R.,Pflantz, T.,Knecht, K.,Digianantonio, K.,Temple, J.,Schneider, C.,Baldauf, H.M.,McLaughlin, K.M.,Rothweiler, F.,Bilen, B.,Farmand, S.,Bojkova, D.,Costa, R.,Ferreiros, N.,Geisslinger, G.,Oellerich, T.,Xiong, Y.,Keppler, O.T.,Wass, M.N.,Michaelis, M.,Cinatl Jr., J. Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells. J Exp Clin Cancer Res, 40:317-317, 2021 Cited by PubMed: 34641952DOI: 10.1186/s13046-021-02093-4 PDB entries with the same primary citation |
Experimental method |
Structure validation
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