7S2K

Crystal structure of sulfonamide resistance enzyme Sul2 in complex with 7,8-dihydropteroate, magnesium, and pyrophosphate

7S2K の概要

• エントリーDOI: 10.2210/pdb7s2k/pdb
• 関連するPDBエントリー: 7S2J
• 分子名称: Sul2, 7,8-DIHYDROPTEROATE, PYROPHOSPHATE 2-, ... (8 entities in total)
• 機能のキーワード: tim barrel, alpha beta protein, antibiotic resistance, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
• 由来する生物種: uncultured bacterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58096.56

構造登録者

Stogios, P.J.,Skarina, T.,Michalska, K.,Venkatesan, M.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2021-09-03, 公開日: 2023-05-03, 最終更新日: 2023-10-25)

• 主引用文献: Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A.; Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.; Nat Commun, 14:4031-4031, 2023; PubMed: 37419898; DOI: 10.1038/s41467-023-39778-7

実験手法

X-RAY DIFFRACTION (1.74 Å)