7S1N

N-Aromatic-Substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable JNK3 Inhibitors

7S1N の概要

• エントリーDOI: 10.2210/pdb7s1n/pdb
• 分子名称: Mitogen-activated protein kinase 10, 4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: mapk10, jnk3, kinase inhibitor, alzheimers diseases, indazole, azaindazole, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53107.24

構造登録者

Park, H. (登録日: 2021-09-02, 公開日: 2021-11-03, 最終更新日: 2023-10-18)

• 主引用文献: Feng, Y.,Park, H.,Ryu, J.C.,Yoon, S.O.; N -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.; Acs Med.Chem.Lett., 12:1546-1552, 2021; PubMed: 34676036; DOI: 10.1021/acsmedchemlett.1c00334

実験手法

X-RAY DIFFRACTION (2.11 Å)